2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-131252
    Dihydro Donepezil 120012-04-6 98%
    Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively.
    Dihydro Donepezil
  • HY-131254
    (S)-O-Desmethyl Venlafaxine N-Oxide 1021934-03-1 98%
    (S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (S)-O-Desmethyl Venlafaxine N-Oxide
  • HY-131287
    MGS0028 321963-33-1 98%
    MGS0028 is a selective metabotropic glutamate 2/3 (mGlu2/3) receptor agonist. MGS0028 can be used for psychiatric disorders research.
    MGS0028
  • HY-131292
    Ro-65-3479 259134-85-5 98%
    Ro-65-3479 is a selective group II metabotropic glutamate receptor (mGlu2/3) antagonist. Ro-65-3479 blocks glutamate-induced signaling and modulates calcium channel activity. Ro-65-3479 is promising for research of disorders involving glutamatergic dysregulation, such as anxiety, schizophrenia, and neurodegenerative diseases.
    Ro-65-3479
  • HY-131293
    MGS0008 234085-20-2 98%
    MGS0008 is an orally active and brain-penetrant metabotropic glutamate receptor 2/3 (mGlu2/3) agonist. MGS0008 is promising for research of central nervous system disorders, including schizophrenia, anxiety, and neurodegenerative diseases.
    MGS0008
  • HY-131305
    HBDDE 154675-18-0 98.03%
    HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
    HBDDE
  • HY-131528
    Tenilsetam 86696-86-8 98%
    Tenilsetam (CAS 997) is an antidementia compound. Tenilsetam is an advanced glycation end product (AGE) inhibitor. Tenilsetam inhibits early retinopathy in experimental diabetes rats.
    Tenilsetam
  • HY-131574
    Heliosupine N-oxide 31701-88-9 98%
    Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC50 of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA).
    Heliosupine N-oxide
  • HY-131622
    7-Aminoclonazepam 4959-17-5 98%
    7-Aminoclonazepam is a major metabolite of Clonazepam that can be for the assessment of Clonazepam use.
    7-Aminoclonazepam
  • HY-131624
    LON 954 63504-15-4 98%
    LON 954, a tremorogenic agent, is a reversible monoamine oxidase (MAO) inhibitor. LON 954 inhibits MAO activity in various tissue preparations.
    LON 954
  • HY-131629
    N-Desmethyl-U-47700 67579-73-1 98%
    N-Desmethyl-U-47700 is the primary metabolite of U-47700 (an opioid agonist).
    N-Desmethyl-U-47700
  • HY-131631
    Desmethyl cyclobenzaprine hydrochloride 438-59-5 98%
    Desmethyl cyclobenzaprine hydrochloride is a metabolite of Amitriptyline (HY-B0527). Desmethyl cyclobenzaprine hydrochloride can be used in the research of depression.
    Desmethyl cyclobenzaprine hydrochloride
  • HY-131930
    AH-8533 759397-79-0 98%
    AH-8533 is a opioid agent.
    AH-8533
  • HY-131931
    Lysoganglioside-GM1 potassium 171483-40-2 98%
    Lysoganglioside-GM1 (LysoGM1) potassium is a derivative of Monosialoganglioside GM1, which lacks a fatty acid. Lysoganglioside-GM1 potassium is also an inhibitor of GM1 aggregation. Lysoganglioside-GM1 potassium can inhibit the activation of Lyn and laminin-1-mediated neurite outgrowth. Lysoganglioside-GM1 potassium can be used in the research of nervous system diseases.
    Lysoganglioside-GM1 potassium
  • HY-131942
    sFTX-3.3 141997-14-0 98%
    sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.
    sFTX-3.3
  • HY-131947
    DH97-7 343263-95-6 98%
    DH97 is a potent melatonin receptor 2 (MT2) antagonist with Ki values of 252 nM and 1100 nM for MT2 and MT1, respectively.
    DH97-7
  • HY-131954
    5-HT3 antagonist 4 930478-88-9 98%
    5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice.
    5-HT3 antagonist 4
  • HY-131997
    2'MeO6MF 89112-85-6 98%
    2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response.
    2'MeO6MF
  • HY-13200A
    BRL-15572 hydrochloride 1173022-77-9 98%
    BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.
    BRL-15572 hydrochloride
  • HY-13200B
    BRL-15572 734517-40-9 98%
    BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.
    BRL-15572
Cat. No. Product Name / Synonyms Application Reactivity